Adverse Event Reporting

VAERS ID	1756520
Gender	Male
Age	66
StateCode
Pharmaceutical Company	PFIZER\BIONTECH
Lot Number
Number of vaccinations	1
Vaccinated	2021-09-10
Onset	2021-09-22
Condition	Hospitalized Life Threatening Permanent Disability

Symptoms

• Intensive care
• Asthenia
• Endotracheal intubation
• Immunoglobulin therapy
• Herpes simplex test negative
• Respiratory failure
• Lumbar puncture
• Magnetic resonance imaging spinal abnormal
• Areflexia
• CSF red blood cell count positive
• CSF white blood cell count increased
• Treponema test negative
• Varicella virus test negative
• Guillain-Barre syndrome
• Respiratory disorder
• Cytomegalovirus test negative
• CSF protein increased
• Spinal osteoarthritis
• Vertebral foraminal stenosis
• CSF glucose increased

Current Illness

none

Preexisting Conditions

HTN, chronic back pain, BPH, CAD, HLD

Other Medications

aspirin, atorvastatin, carvedilol, diazepam, finasteride, HCTZ, lisinopril, Morphine ER, phenazophyridine, tamsulosin, ticagrelor

Previous Vaccinations

Allergies

fentanyl

Laboratory Data

Lumbar Puncture 9/24/21: Protein 81, WBC 24-- >3 (tube 1-- >tube 4), RBC 29-- >0 (tube 1-- >tube 4), glucose 90.
CSF HSV and VZV negative.
Serum CMV negative.
VDRL CSF negative.
MRI cervical spine 9/23/21: acquired and multilevel sponylosis of cervical spine.
Varying degrees of central and neural foraminal stenosis.
No cord signal abnormality.

Write-up

Patient had Johnson and Johnson vaccination in April 2020- single dose.
2 weeks prior to presentation, he was recommended to receive a Pfizer booster shot.
On presentation, he had rapidly progressive ascending weakness/paralysis with respiratory compromise over ~48 hours leading to respiratory failure and need for intubation.
He also lost his reflexes while in the hospital.
His diagnosis is consistent with Guillain-Barre Syndrome.
He received 2gm/kg IVIG over 5 days.
He is improving and yesterday was extubated but is still profoundly weak and remains in the ICU currently.